Postdoc - Developmental Biology and Disease Modeling (m/f/d)

We are looking for an enthusiastic postdoc to join our research group at the Institute of Human Genetics of the University Heidelberg (Germany) to study the pathophysiology of Cornelia de Lange Syndrome (CdLS).

Following generation of CRISPR/Cas9 engineered human induced pluripotent stem cells (hiPSC) with CdLS mutations, the successful candidate will characterize the hiPSC as well as hiPSC-derived neural crest cells (NCC) by HiChIP-seq, RNA-seq, and ATAC-seq. Integrative analysis of these data should reveal the regulatory networks controlled by cohesin in hiPSC and hiPSC-derived NCC.
Our laboratory explores early human development using hiPSC and their differentiation to understand gene regulation by non-coding DNA elements and the 3D chromosomal architecture in health and disease. We incorporate cutting-edge methods from various disciplines (cell biology, genomics, gene editing, bioinformatics, network biology) to provide a holistic picture of the most fundamental developmental processes.

Composed of international and multi-disciplinary scientists, our group creates a unique and inspiring environment and supports individual career development. For more information visit:

https://www.klinikum.uni-heidelberg.de/humangenetik/forschung/ag-laugsch

Project relevant literature

doi: 10.1016/j.stem.2019.03.004.

doi: 10.1177/00220345211038203.

doi: 10.1371/journal.pone.0065149.

• Ph.D.in bioscience or equivalent degree with substantial experience in stem cell biology and basic bioinformatics
• Cell culture experience and standard molecular biological techniques such as cloning, microscopy, Western blot, immunofluorescence, qPCR is a must
• Experience in at least one of the following techniques is required: ChIP-seq, ATAC-seq, Hi-C, or 4C-seq is required
• Experience in hiPSC culture, CRISPR/Cas9 targeting and their differentiation is a huge advantage
• Ability to analyze own sequencing data as well as strong interest in Python, R, shell scripting and working with NGS data
• Curiosity-driven researcher, passionate about science, who can work both independently and as part of our team
• Strong written and verbal communication skills in English

• Goal-oriented, individual training and development opportunities
• Working with the latest techniques / technical equipment
• Possibility to publish scientifically is offered and supported
• Regular team meetings
• Collectively agreed remuneration, attractive company pension scheme (VBL)
• 30 days vacation
• Sustainable travel: job ticket
• Family-friendly working environment: cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of care
• Wide range of health, prevention and sports offers

For further information please contact Dr. Magdalena Laugsch via e-mail. The application must include your motivation, a brief statement of your scientific interests including your contribution to the projects you were working on and how you can contribute to the cohesin project. In addition, contact details from three references, curriculum vitae, separated publication list, and relevant certificates. Please forward your complete application in a single document with filename: Postdoc_Cohesin25_first name_second name (so other format will be accepted by e-mail to Magdalena.laugsch@uni-heidelberg.de.)

Interested?

Applications will be accepted until 28.02.2025 via e-mail.