PhD Student (m/f/d)
wanted at the Department of Endocrinology and Metabolism in our lab at the Joint Heidelberg IDC Translational Diabetes Program.
We are excited to announce an opening for a PhD student to join our dynamic research team at Joint Heidelberg-IDC Translational Diabetes Program at Heidelberg University Hospital. If you are passionate about unraveling the molecular mechanisms underlying metabolic disorders and eager to contribute to cutting-edge advancements in translational research, we want to hear from you!
- Job-ID: V000013607
- Field of application: Klinik für Endokrinologie, Diabetologie, Stoffwechselkrankheiten und Klinische Chemie
- Location: Heidelberg
- Job Category: Science and teaching
- Working hours: full-time
- Published: 18.12.2024
- Limitation:Temporary (3 Jahre)
Your tasks
TSC22D4 is an evolutionarily conserved protein with a long stretch of intrinsically disordered region (IDR) which contains multiple phosphorylation sites. Patients with type 2 diabetes and liver fibrosis have elevated TSC22D4 protein levels in their liver. In this project, you will investigate whether phosphorylation of TSC22D4 contributes to liver fibrosis by performing experiments both in the cell culture and in mouse models. The tasks will involve overexpressing wild type, phospho-defective, and phospho-mimetic TSC22D4 mutants in primary hepatocytes or in mouse livers to address whether TSC22D4 phosphorylation plays role in apoptosis, inflammation and liver injury. The techniques for these measurements will mostly include RNA and protein extraction from the cells or the liver tissue, qPCR analysis, western blotting, ELISA, and immunohistocemical stainings.
Your Profile
- A highly motivated and hardworking student with a Msc degree in biological sciences and a strong academic background in molecular and cellular biology.
- Demonstrated interest and experience in metabolism research including cell culture work and mouse models as well as excellent communication and teamwork skills.
What we offer
- Goal-oriented, individual training and development opportunities (e.g. Enrollment opportunity at HBIGS Graduate School)
- Possibility to publish scientifically is offered and supported
- Regular team meetings
- Interdisciplinary cooperation with Helmholtz Diabetes Center, Munich
- The opportunity to work on translational research from bench to bedside
- Collectively agreed remuneration, attractive company pension scheme (VBL)
- 30 days vacation
- Sustainable travel: job ticket
- Family-friendly working environment: cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of care
- Wide range of health, prevention and sports offers
Contact & Application
For further information please contact Dr. Bilgen Ekim via email.
Interested?
Applications will be accepted until 31.01.2025 via e-mail.
Klinik für Endokrinologie, Diabetologie, Stoffwechselkrankheiten und Klinische Chemie
69120 Heidelberg
bilgen.ekim@med.uni-heidelberg.de
Note: The UKHD is subject to the provisions of the Infektionsschutzgesetz. Therefore, a valid measles immunity certificate is required for all persons employed at the UKHD.
The UKHD embraces diversity and values diversity.
Regardless of age, gender, sexual identity, disability, origin or religion, we offer everyone the same opportunities. If one gender is underrepresented in a particular area, we place particular emphasis on counteracting this imbalance. If they have the same aptitude, qualifications and professional performance, we give priority to people with severe disabilities when considering them for vacancies.
