Postdoc position (m/w/d)
Investigating early oocyst development of Plasmodium.
Malaria is a devastating infectious disease that kills more than half a million people per year. It is caused by the eukaryotic, single-celled parasite Plasmodium, which infects mosquitoes to spread from host to host. At the Hentzschel lab, we investigate the biology of early mosquito infection, particularly how the extracellular form of the parasite, the oocyst, develops at the mosquito midgut. The oocyst is a post-meiotic, but still diploid cell, and how this unusual cell biology is organised and transcriptionally regulated is still not well understood. We have previously identified that parasites lacking parts of the male genome still form oocysts and arrest much later than thought. We now want to understand the molecular and cellular processes underlying this phenotype, which will not only reveal non-textbook cell biology, but might help to develop transmission-blocking drugs in the future.
What we offer
During your fully funded postdoc project (4 years, 100 %), you will develop and use state-of-the-art molecular biology, quantitative live-cell microscopy, transcriptomics, and genetic tools to investigate the cell biology of oocyst development. You will join a young, dynamic group with plenty of opportunities to bring in your own ideas. You can expect a supportive environment and both close mentoring to comprehensively expand your scientific and professional skills, and freedom to develop your own line of research. There will be opportunities to participate in international meetings to extend your scientific network and visibility in the field. Our lab is part of the parasitology department at the Center for Infectious Diseases, located in the new CIID building on the Neuenheimer Feld Campus in Heidelberg. Here you will be part of a vibrant parasitology community and have access to all necessary facilities and equipment. Heidelberg University also has a variety of career development opportunities for postdocs and early career scientists. The postdoc position is funded by an ERC Starting Grant and should start between April and December 2025.
More information about the lab and the project can be found on the lab website
- Job-ID: V000013422
- Field of application: Zentrum für Infektiologie
- Location: Heidelberg
- Job Category: Science and teaching
- Working hours: full-time
- Published: 31.10.2024
- Limitation:Temporary (3 years)
- Contract:TV-L
Your tasks
- Characterisation of rodent Plasmodium berghei parasites in mouse and mosquito vectors
- Cultivation of human-infecting Plasmodium falciparum parasites in cell culture (S2)
- Generation and characterisation of transgenic berghei and P. falciparum lines
- State-of-the-art widefield, confocal and super-resolution microscopy
- Preparation of scientific presentations and manuscripts for publication
Your profile
- Curiosity, passion and enthusiasm for unusual cell biology
- PhD in molecular or cellular biology
- Self-driven motivation, initiative and willingness to drive the project forward
- Ability to work both independently as well as collaboratively in a team
- Good communication skills in English (speaking, reading, writing)
- Willingness to work with experimental mouse models
- Prior experience with molecular biology essential, experience with parasitology, transcriptomics, or live-cell microscopy desirable
We offer
- Goal-oriented, individual training and development opportunities (e.g. career courses)
- Working with the latest techniques / technical equipment state-of-the-art confocal and super-resolution microscopy
- Flexible working hours within the framework of flexitime
- Possibility to publish scientifically is offered and supported
- Regular team meetings
- (Partial) project management / project responsibility possible if suitable
- Participation in national or international conference and collaboration
- Collectively agreed remuneration, attractive company pension scheme (VBL)
- 30 days vacation
- Sustainable travel: job ticket
- Family-friendly working environment: cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of care
- Wide range of health, prevention and sports offers
Contact & Application
For further information please contact Franziska Hentzschel via email.
Interested?
Applications will be accepted until 31.01.2025 via e-mail.
Zentrum für Infektiologie
Franziska Hentzschel, Group Leader
Im Neuenheimer Feld 324
69120 Heidelberg
franziska.hentzschel@med.uni-heidelberg.de
Note: The UKHD is subject to the provisions of the Infektionsschutzgesetz. Therefore, a valid measles immunity certificate is required for all persons employed at the UKHD.
The UKHD embraces diversity and values diversity.
Regardless of age, gender, sexual identity, disability, origin or religion, we offer everyone the same opportunities. If one gender is underrepresented in a particular area, we place particular emphasis on counteracting this imbalance. If they have the same aptitude, qualifications and professional performance, we give priority to people with severe disabilities when considering them for vacancies.