Research Technician (m/f/d)

at the earliest possible date searched for the Institute of Experimental Cardiology.

Cardiovascular diseases are the leading cause of death in Western Countries and represent one of the major medical challenges of our time. The Institute for Experimental Cardiology studies the molecular basis of different forms of cardiac diseases and develops novel therapeutic approaches. We are embedded in the German Center for Cardiovascular Research (DZHK), the Collaborative Research Center 1550 and the Helmholtz Institute for Translational AngioCardioScience (HI-TAC), providing an ideal infrastructure for innovative translational research.

Highly standardized preclinical animal models play a pivotal role in our basic and translational research projects. We are seeking an experienced and highly motivated research technician to join our team at the earliest possible date. You will perform methods of disease modeling in small animals including surgery procedures and apply various cardiovascular phenotyping techniques. You will be further responsible for coordinating genetic mouse lines, including organization of mouse breeding and maintenance, and supervision of genotyping. The ideal candidate should be experienced with small animal surgery, and further be familiar with principles of mouse transgenic technologies. Experience in cardiovascular disease modeling is a big plus.

The institute has long lasting experience in transgenic mouse models and preclinical in vivo models of cardiovascular diseases. We apply state-of-the-art techniques to engineer transgenic animals and have profound expertise in CRISPR/Cas9-based gene editing and gene therapy to study molecular mechanisms of heart diseases and develop novel therapies. In our small animal model and phenotyping core we have established multiple genetic, pharmacological and surgical small animal models to study heart diseases and to validate newly developed therapeutic approaches. Our small animal core is equipped with all state-of-the-art technologies for comprehensive cardiovascular preclinical in vivo research (e.g. mouse microsurgery platforms, VisualSonics Vevo echocardiography setup, DSI PhysioTel telemetry system). The person joining will be part of an established core with standardized procedures and will be supervised by experienced personnel.